Prurigo pigmentosa is a rare skin condition of unknown cause, characterized by the sudden onset of erythematous papules that leave a reticulated hyperpigmentation when they heal. The condition has been associated with a strict ketogenic diet in case reports in the medical literature.
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Prurigo pigmentosa 是一種罕見的發炎性皮膚病,於 1971 年由 Nagashima 等人首次報告。此病常於頸部、胸部及背部出現對稱性凸起的紅色腫塊樣皮疹,形成網狀圖案,病變可時隱時現,且會在皮膚上留下深色斑塊。Prurigo pigmentosa 可能與代謝變化有關,例如近年流行的生酮飲食所引發的代謝改變。 Prurigo pigmentosa, also known as Nagashima disease or keto rash, is a rare inflammatory skin disease initially described by Nagashima et al in 1971. Prurigo pigmentosa typically, but not exclusively, affects young females of East Asian ethnicity, presenting as a symmetrical eruption of urticarial papules on the neck, chest, and back. The papular eruption typically coalesces into a reticulated pattern that repeatedly resolves and recurs, resulting in hyperpigmented skin of cosmetic concern. Prurigo pigmentosa can be triggered by metabolic derangements, including those secondary to ketogenic diets, which have experienced a rise in popularity in recent years.
Prurigo pigmentosa 是一種皮膚病,會導致突然出現發癢的網狀紅色腫塊,隨後形成黑斑。近來有研究顯示 Prurigo pigmentosa 與生酮飲食相關。此病可影響任何年齡與性別的人,女性較常見。若恢復正常飲食或局部皮膚治療效果不佳,醫師可能會開口服抗生素,如 doxycycline(多西環素)或 minocycline(米諾環素),劑量為每次 100 毫克,每日兩次,療程持續 1 至 2 個月。 Prurigo pigmentosa is a skin condition causing sudden, itchy, red bumps in a net-like pattern followed by dark spots. Lately, some evidences were founded that Prurigo pigmentosa is associated with the ketogenic diet. It can affect people of different ages and genders, with a tendency to be more common in females. In cases where returning to a regular diet or using skin treatments doesn't fully help, doctors may prescribe a course of oral antibiotics like doxycycline or minocycline (100 mg twice daily for 1 to 2 months).